Calcagno Lab

Biography

Dr. Calcagno, MD, PhD, is an Instructor of Radiology at the Icahn School of Medicine at Mount Sinai. She was trained in Medicine and Surgery at the University of Genoa, Italy and holds a PhD in Computational Biology from the Mount Sinai Graduate School of Biological Sciences/New York University. Her research focuses on the development and application of non-invasive quantitative imaging to cardiovascular disease, with specific focus on the measurement of atherosclerotic plaque permeability and inflammation with MRI (Calcagno et al, Arterioscl Thromb Vasc Biol, 2008) and PET (Calcagno C et al Eur J Nucl Med Mol Imaging 2013). She has been extensively involved in applying these techniques in pre-clinical drug trials in atherosclerotic rabbits (Lobatto M et al, Mol Pharm, 2010; Vucic E et al, JACC Cardiovasc Imaging 2011 and 2012), and clinical trials in humans (der Valk FM et al, Nanomedicine, 2015). As a post-doctoral fellow, Dr. Calcagno was supported by a prestigious fellowship from the American Heart Association (2013-2015), which focused on optimizing and validating 3 dimensional, fast MR image acquisition for atherosclerosis using compressed sensing reconstruction (Kim Y et al, Proc Nati Acad Sci U S A, 2014; Lobatto ME, Calcagno C et al, ACS Nano, 2015). During this time, together with other collaborators at Mount Sinai, she also worked on validating novel PET/MRI to quantify plaque inflammation (Bini J et al, Int J Cardiovasc Imaging, 2015). Dr. Calcagno was recently awarded a highly competitive Scientist Development Grant from the American Heart Association. By taking advantage of an optmimized self-gated acquisition and compressed sensing reconstruction, this application aims to develop high temporal and spatilal resolution DCE-MRI to quantify endothelial permeability in the aortic root of atherosclerotic mice. By investigating the relationship between imaging, and genetics, cellular and molecular assays in the arterial wall, the application also aims to take the first step in integrating quantitative, non-invasive imaging with -omics in this important animal model of cardiovascular disease.

Funding

January 2016
16SDG27250090 Scientist Development Grant (Calcagno) 2016- 2018 American Heart Association: Quantitative permeability imaging of the mouse atherosclerotic vessel wall
July 2013
13POST16340006 Post-doctoral Fellowship (Calcagno) 2013- 2015 American Heart Association

Awards

July 2004
Graduated summa cum laude, University of Genova, Genova, Italy (Medical Degree)
July 2004
Medal for Excellence in Education, from the Faculty Members of the University of Genova, Genova, Italy
August 2013
25th Annual Meeting of the International Magnetic Resonance Angiography Working Group, Young Investigator Award
May 2014
Distinguished Research Presentation, Cardiac MR Study Group Meeting, 22nd International Society for Magnetic Resonance in Medicine (ISMRM) Meeting, 2014, Milan
May 2014
Second prize winner, The Great Italian Art and Food Challenge, 22nd International Society for Magnetic Resonance in Medicine (ISMRM) Meeting, 2014, Milan
June 2015
“Self-gated dynamic contrast enhanced (DCE) MRI with compressed sensing acceleration to quantify permeability in the aortic root of atherosclerotic mice”, selected for oral presentation at the 23rd Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM), 2015, Toronto, and awarded the ISMRM Merit Award “Magna Cum Laude” (abstract # 0560)

Publications (full list)

  1. Detection of neovessels in atherosclerotic plaques of rabbits using dynamic contrast enhanced MRI and 18F-FDG PET. Calcagno C, Cornily JC, Hyafil F, Rudd JH, Briley-Saebo KC, Mani V, Goldschlager G, Machac J, Fuster V, Fayad ZA. Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1311-7. doi: 10.1161/ATVBAHA.108.166173. Epub 2008 May 8. PMID: 18467641, featured on printed magazine cover
  2. Evaluation of neovessels in atherosclerotic plaques of rabbits using an albumin-binding intravascular contrast agent and MRI. Cornily JC, Hyafil F, Calcagno C, Briley-Saebo KC, Tunstead J, Aguinaldo JG, Mani V, Lorusso V, Cavagna FM, Fayad ZA. J Magn Reson Imaging. 2008 Jun;27(6):1406-11. doi: 10.1002/jmri.21369. PMID: 18504763
  3. Reproducibility of black blood dynamic contrast-enhanced magnetic resonance imaging in aortic plaques of atherosclerotic rabbits. Calcagno C, Vucic E, Mani V, Goldschlager G, Fayad ZA. J Magn Reson Imaging. 2010 Jul;32(1):191-8. doi: 10.1002/jmri.22225. PMID: 20578026
  4. Three dimensional (3D) dynamic contrast enhanced (DCE) MRI for the accurate, extensive quantification of microvascular permeability in atherosclerotic plaques, Calcagno C, Lobatto M, Dyvorne H, Robson PM, Millon A, Senders M, Lairez O, Ramachandran S, Coolen B, Black A, Mulder W, Fayad ZA, NMR Biomed. 2015 Oct;28(10):1304-14. doi: 10.1002/nbm.3369. Epub 2015 Aug 30. PMID:26332103
  5. Pharmaceutical development and preclinical evaluation of a GMP-grade anti-inflammatory nanotherapy Lobatto ME, Calcagno C, Otten MJ, Millon A, Ramachandran S, Paridaans MP, van der Valk FM, Storm G, Stroes ES, Fayad ZA, Mulder WJ, Metselaar JM., Nanomedicine. 2015 Jul;11(5):1133-40. doi: 10.1016/j.nano.2015.02.020. Epub 2015 Mar 17. PMID: 25791805
  6. Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging. Lobatto ME, Calcagno C, Millon A, Senders ML, Fay F, Robson PM, Ramachandran S, Binderup T, Paridaans MP, Sensarn S, Rogalla S, Gordon RE, Cardoso L, Storm G, Metselaar JM, Contag CH, Stroes ES, Fayad ZA, Mulder WJ. ACS Nano. 2015 Feb 24;9(2):1837-47. doi: 10.1021/nn506750r. Epub 2015 Jan 28. PMID: 25619964
  7. Prednisolone-containing liposomes accumulate in human atherosclerotic macrophages upon intravenous administration.der Valk FM, van Wijk DF, Lobatto ME, Verberne HJ, Storm G, Willems MC, Legemate DA, Nederveen AJ, Calcagno C, Mani V, Ramachandran S, Paridaans MP, Otten MJ, Dallinga-Thie GM, Fayad ZA, Nieuwdorp M, Schulte DM, Metselaar JM, Mulder WJ, Stroes ES. Nanomedicine. 2015 Mar 17. pii: S1549-9634(15)00071-4. doi: 10.1016/j.nano.2015.02.021. [Epub ahead of print] PMID: 25791806
  8. Tang J, Lobatto ME, Hassing L, van der Staay S, van Rijs SM, Calcagno C, Braza MS, Baxter S, Fay F, Sanchez-Gaytan BL, Duivenvoorden R, Sager HB, Astudillo YM, Leong W, Ramachandran S, Storm G, Pérez-Medina C, Reiner T, Cormode DP, Strijkers GJ, Stroes ES, Swirski FK, Nahrendorf M, Fisher EA, Fayad ZA, Mulder WJM, Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation. Sci Adv 1, e1400223 (2015).
  9. The complementary roles of dynamic contrast-enhanced MRI and 18F-fluorodeoxyglucose PET/CT for imaging of carotid atherosclerosis. Calcagno C, Ramachandran S, Izquierdo-Garcia D, Mani V, Millon A, Rosenbaum D, Tawakol A, Woodward M, Bucerius J, Moshier E, Godbold J, Kallend D, Farkouh ME, Fuster V, Rudd JH, Fayad ZA. Eur J Nucl Med Mol Imaging. 2013 Dec;40(12):1884-93. doi: 10.1007/s00259-013-2518-4. Epub 2013 Aug 14. PMID: 23942908
  10. Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis. Kim Y, Lobatto ME, Kawahara T, Lee Chung B, Mieszawska AJ, Sanchez-Gaytan BL, Fay F, Senders ML, Calcagno C, Becraft J, Tun Saung M, Gordon RE, Stroes ES, Ma M, Farokhzad OC, Fayad ZA, Mulder WJ, Langer R. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1078-83. doi: 10.1073/pnas.1322725111. Epub 2014 Jan 6. PMID: 24395808
  11. Atherosclerotic plaque targeting mechanism of long-circulating nanoparticles established by multimodal imaging. Lobatto ME, Calcagno C, Millon A, Senders ML, Fay F, Robson PM, Ramachandran S, Binderup T, Paridaans MP, Sensarn S, Rogalla S, Gordon RE, Cardoso L, Storm G, Metselaar JM, Contag CH, Stroes ES, Fayad ZA, Mulder WJ. ACS Nano. 2015 Feb 24;9(2):1837-47. doi: 10.1021/nn506750r. Epub 2015 Jan 28. PMID: 25619964
  12. 12. Simultaneous carotid PET/MR: feasibility and improvement of magnetic resonance-based attenuation correction. Bini J, Eldib M, Robson PM, Calcagno C, Fayad ZA. Int J Cardiovasc Imaging. 2015 Apr 22. [Epub ahead of print] PMID: 25898892

Lab members

Alison Pruzan

Alison PruzanBS, Associate Researcher

Gilles Boeykens

Gilles BoeykensMedical Student

ADDRESS

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