TMII FRONTIERS OF IMAGING SEMINAR SERIES "Towards Preventive Healthcare: An Integrated Multi-modal Approach"

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Sept. 27, 2018 from noon to 1 p.m.

Address
Seminar Room B – 2nd Floor
Hess Center for Science & Medicine
1470 Madison Avenue, New York, NY
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Speakers
  • David S. Karow, MD, PhD
  • Interim Chief Executive Officer
  • Human Longevity, Inc.
  • San Diego, California
RSVP

Despite the enormous cost of U.S. healthcare (over $3 trillion in 2016), one-third of individuals aged 50-75 in the United States die prematurely from age-related chronic diseases. The overwhelming cost of the current health system is due, at least partly, to its tendency to be more reactive than proactive, and the usage of medical imaging and clinical tests has classically focused on patient cohorts that already display disease symptoms. We present a unique platform of deep quantitative multimodal phenotyping that provides a comprehensive, predictive, preventive, and personalized assessment of an individual's health status. The offered multimodal assays include whole genome sequencing (WGS), advanced imaging, metagenomic sequencing, metabolome, electrocardiogram, and clinical labs as well as detailed personal and family medical history. Highlighting the value of using a multimodal approach, we show how we have used these data to create an integrated risk report for an individual’s risk of short-term cognitive decline and lifetime risk of developing dementia. We leveraged known genetic variants associated with the risk of Alzheimer’s and features from structural magnetic resonance images of the brain (MRI) including surface area, thickness, and volume of regions of interest, as well as demographics and modifiable risk factors. In all cases, the combination of MRI and genetics data improved performance in the prediction of dementia progression over either element alone.

ADDRESS

  • Address: Leon and Norma Hess Center for Science and Medicine 1470 Madison Avenue (between 101st and 102nd St) TMII - 1st Floor New York,
    NY 10029
  • Email: TMII@mssm.edu
  • Website: tmii.mssm.edu
  • Tel: (212) 824-8471
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