“High-Resolution Volumetric Imaging of Endogenous Metabolites with Chemical Exchange Saturation Transfer (CEST)”

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Aug. 9, 2016 from 10 a.m. to 11 a.m.

Address
Hess 1st Floor
TMII Large Conference Room 117
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Speakers
  • Feliks Kogan, PhD
  • Physical Research Associate
  • Department of Radiology
  • Stanford Univeristy
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Abstract: Many methods have been proposed for non-invasive molecular imaging in vivo, but few so far have robust applications in the clinical setting. Chemical Exchange Saturation Transfer (CEST) is a new contrast enhancement technique that enables the indirect detection of molecules with exchangeable protons. CEST provides an opportunity to make MRI sensitive to the concentrations of endogenous metabolites and their environments. I will give a background to CEST imaging and discuss the challenges that are present in the field. I will also review potential endogenous in vivo CEST applications to imaging numerous metabolites including glutamate (Glu), myo-inositol (MI), creatine (Cr), glycosaminoglycans (GAG), glycogen, and glucose. Finally, I will discuss new methods that our group has developed at Stanford that allow for rapid, volumetric CEST acquisitions to enhance the clinical translation of the technique.

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  • Address: Leon and Norma Hess Center for Science and Medicine 1470 Madison Avenue (between 101st and 102nd St) TMII - 1st Floor New York,
    NY 10029
  • Email: TMII@mssm.edu
  • Website: tmii.mssm.edu
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