TMII LECTURE SEMINAR SERIES

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July 7, 2016 from 1 p.m. to 2 p.m.

Address
Hess Davis Center
2nd Floor – Seminar Room B
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Speakers
  • Hyunsuk Shim, PhD
  • Professor, Department of Radiology and Imaging Sciences
  • Emory University School of Medicine
  • Atlanta, Georgia
RSVP

Critical Unmet Needs for treatment planning imaging in GBM patients and Spectroscopic MRI


Abstract: Metabolic reprogramming is considered to be a hallmark of cancer and a potential source of novel targets for diagnostic imaging and therapy in cancer. Imaging informative aspects of metabolism report on biologically and clinically important features of tumor biology, enabling both prognostic counseling and tailoring of therapeutic regimens. Metabolic imaging therefore has the potential to provide a new dimension of precision medicine. For brain tumor patient management, we have serious issues of using conventional diagnostic images (contrast-enhanced T1w-MRI and T2/FLAIR) for surgery and radiation therapy (RT) guidance. Especially, radiation therapy (RT) is as good as the images that guide RT planning. RT based on conventional MRIs may not fully target tumor extent in glioblastomas (GBM), which may, in part, account for high recurrence rates (60-70 percent at 6 months). Magnetic resonance spectroscopy, a molecular imaging modality that quantifies endogenous metabolite levels without relying on perfusion, leakage and diffusion of injected material, may better define extent of metabolically active tumor. In addition, advances in this technology now permit acquisition of whole-brain high-resolution 3D spectroscopic MRI (sMRI) in 12-14 minutes. We correlated state-of-the-art sMRI metabolite maps and their ratio maps with tissue histopathology to validate further its use for identifying non-enhancing and infiltrating tumors that may not be fully imaged by conventional MRI sequences and provide support for its adjunctive use in tumor contouring for RT planning. Integration of histologically-verified, whole brain 3D sMRI into RT planning is feasible and may considerably modify target volumes. Thus, RT planning for GBMs may be augmented by sMRI potentially leading to reduced or delayed recurrence rates. Hosted By: Zahi Fayad, PhD Contact: Sybil Price (212) 824-8471 sybil.price@mssm.edu

ADDRESS

  • Address: Leon and Norma Hess Center for Science and Medicine 1470 Madison Avenue (between 101st and 102nd St) TMII - 1st Floor New York,
    NY 10029
  • Email: TMII@mssm.edu
  • Website: tmii.mssm.edu
  • Tel: (212) 824-8471
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