May 20, 2015 from 11:30 a.m. to 12:30 p.m.
Hess Center for Science and Medicine
Icahn School of Medicine at Mount Sinai
- Nellie Byun, PhD
- Associate Professor
- Vanderbilt Center for Drug Discovery
- Vanderbilt University Institute of Imaging Science
- Department of Pharmacology
- Vanderbilt University Medical Center
Abstract: The primary focus of my research is to develop a detailed understanding of the changes in brain circuits and neurotransmission underlying brain disorders and their treatments. Our laboratory quantifies engagement of neural circuits and brain regions, as well as vascular and diffusion effects, using various in vivo functional MRI techniques, in response to novel compounds, focusing on selective allosteric activators and modulators of individual metabotropic glutamate and muscarinic acetylcholine receptors. We also probe cognition, behavior, and physiology. In addition to the basic science efforts of measuring central drug effects and the interplay between different neurotransmitter systems, another goal is to use this data to advance translational biomarkers across species for potential clinical studies for novel treatments of schizophrenia (M4 muscarinic, mGlu2, and mGlu5 potentiators) and Parkinson’s Disease (mGlu4 potentiators) in academic and industry partnered efforts.