Feb. 18, 2015 from 9:45 a.m. to 10:45 a.m.
Hess Conference Center
2nd Floor – Seminar Room A
- Frederik Beekman, PhD
- Delft University of Technology
Abstract. Pivotal questions in pharmacology and biology concern how function of localized cells relates to disease. In experimental neuroscience we have dreamt about a magnifying glass that would allow us to see neurotransmitters in action, in cardiovascular research about a system that would provide us simultaneously with mechanical functions and various cell functions, and in cancer research for simultaneous detailed dynamic distributions of pharmaceuticals and indicators of tumor response. In recent years many groups have been involved in the development of pinhole imaging SPECT systems for imaging rodents. At MILabs and TU-Delft, a line of Ultra-high resolution Single Photon Emission Computed Tomography with integrated X-ray CT (USPECT-CT) has been developed that can quantify tracer dynamics in < quarter mm structures or enable low dose imaging with fractions of a MBq by applying highly advanced multi-pinhole collimators, as well as novel image acquisition and reconstruction methods and developed new ways to perform SPECT imaging simultaneous with sub-mm Positron Emission Tomography (PET). This Versatile Emission Computed Tomography system (dubbed as VECTor) is based on a new clustered multi-pinhole technology and turns out to enable for the first time high energy SPECT at unprecedented resolution. Several scientific results recorded by world wide users of USPECT/CT and VECTor/CT. Examples include high resolution images of glucose and density and occupancy of transporters/receptors in the brain, extremely detailed imaging of myocardial perfusion, tumor markers, anti-cancer agents (e.g. antibodies) as well as imaging very few cells or particles during a range of points in time. In addition novel clinical SPECT systems with approx.. 3mm resolution and multimodal platforms including SPECT, PET, MRI, CT, bioluminescence and fluorescence will be discussed.