“Multi-dimensional (3 Spatial +2 Spectral) MR Spectroscopic Imaging: Implementation and Recent Progress”

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Nov. 19, 2015 from 1 p.m. to 2 p.m.

Address
Hess 1
st Floor
TMII Large Conference Room 117
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Speakers
  • M. Albert Thomas, Ph.D
  • Radiological Sciences, Psychiatry
  • BioMedical Physics and BioEngineering
  • UCLA Geffen School of Medicine
  • University of California, Los Angeles CA
RSVP

Abstract: MR Spectroscopy (MRS) is a powerful and non-invasive biochemical tool. Even though sub-millimeter in-plane resolution is achievable using MRI, MR spectroscopic imaging (MRSI) suffers from poor sensitivity (> 1mM) and inferior spatial resolution (>5mm). In spite of these deficits, MRS/MRSI turns out to be a versatile tool to probe tissue metabolism noninvasively during the past three decades in revealing metabolic abnormalities in cancer, neurological and psychiatric disorders, and other pathologies. First half of this talk will present an overview of recent developments in MRSI/MRS including the applications in brain tumor mutation (1), breast and prostate cancer (2). Spatial encoding along two or three dimensions so far has been combined with one spectral representation only in 2D/3D MRSI. By extending the spectroscopic dimensions to two, it has been shown that metabolites whose resonances overlap and also, those which occur at low concentrations can be detected unambiguously since the resonances from them overlap severely with that of dominant metabolites. Hence, there is a necessity for multivoxel based multidimensional MR spectroscopy in a single measurement with clinically acceptable time, and to record spectroscopic information from a large volume of interest subdivided into an array of smaller voxels (3). Second half of this talk will highlight recent progress on the implementation of multi-voxel based two-dimensional (2D) MR spectroscopy combining two to three spatial and two spectral encodings; our pilot validation of these novel multi-dimensional MR spectroscopic imaging sequences in brain, muscle, breast and prostate cancer using a Siemens 3T MRI scanner will be discussed.

ADDRESS

  • Address: Leon and Norma Hess Center for Science and Medicine 1470 Madison Avenue (between 101st and 102nd St) TMII - 1st Floor New York,
    NY 10029
  • Email: TMII@mssm.edu
  • Website: tmii.mssm.edu
  • Tel: (212) 824-8471
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