“Development of multi-modal techniques for the investigation of brain energetics”

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Nov. 5, 2015 from 1 p.m. to 2 p.m.

Address
Hess 1
st Floor
TMII Large Conference Room 117
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Speakers
  • Jennifer Taylor, Ph.D
  • Wei Chen Lab
  • Biomedical Engineering Graduate Program
  • Center for Magnetic Resonance Research (CMRR)
  • University of Minnesota, Twin Cities
RSVP

Abstract: To study the coupling and interactions between metabolic, hemodynamic, and neuronal activity, we here develop the technology to acquire in vivo MRS simultaneously from two or more nuclei, as well as develop MR-compatible electrodes for neuronal recording in the MR scanner with minimal susceptibility artifacts. We apply these techniques to investigate metabolic trends resulting from a whole brain occlusion in the rat and to study multi-scale responses to changing anesthesia depth. Lastly, we show the first steps in developing an MR-compatible optrode to allow simultaneous MRI, neuronal recording, and optogenetic stimulation. With these new techniques, a wide field of studies becomes feasible to investigate direct neuronal, metabolic, and hemodynamic correlations to advance our understanding of brain function and dysfunction.

ADDRESS

  • Address: Leon and Norma Hess Center for Science and Medicine 1470 Madison Avenue (between 101st and 102nd St) TMII - 1st Floor New York,
    NY 10029
  • Email: TMII@mssm.edu
  • Website: tmii.mssm.edu
  • Tel: (212) 824-8471
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