“Assemblies of Inorganic Nanocrystals as Contrast Agents for Multimodality Medical Imaging”

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March 6, 2015 from 11 a.m. to noon

Address
Hess Center 1st Floor
TMII Large Conference Room 117
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Speakers
  • David Cormode, PhD
  • Assistant Professor
  • Radiology Department
  • Perelman School of Medicine
  • University of Pennsylvania
  • Philadelphia, PA, USA
RSVP

Abstract: Over the past ten years, nanoparticle-based contrast agents medical imaging has become a topic of intense interest. Nanoparticles possess a range of advantages over small molecules as contrast agents. For example, nanoparticles can carry high payloads of contrast generating material, have long circulation half-lives, be efficiently targeted and it is relatively easy to integrate multiple properties into the same platform. In this presentation I will describe our latest results in developing multifunctional nanoparticle contrast agents for a range of techniques, such as magnetic resonance imaging (MRI), computed tomography (CT) and photoacoustics. We synthesize inorganic nanocrystals such as gold, iron oxides, quantum dots and upconverting nanoparticles. We integrate these nanocrystals with lipids, polymers, proteins, fluorophores, drugs and other functional components to create complex architectures. For example, I will describe an approach to integrate gold, iron oxides and quantum dots into the shell of polymer based microbubbles to provide contrast for ultrasound, MRI, computed tomography and fluorescence-based methods. The applications of such multi-functional nanostructures in targeted imaging, cell tracking and as ‘theranostic’ agents in cardiovascular disease and cancer will be described.

ADDRESS

  • Address: Leon and Norma Hess Center for Science and Medicine 1470 Madison Avenue (between 101st and 102nd St) TMII - 1st Floor New York,
    NY 10029
  • Email: TMII@mssm.edu
  • Website: tmii.mssm.edu
  • Tel: (212) 824-8471
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